Jun Wang

This study identifies OSTM1 as a tumor suppressor in B-cell malignancies by showing it activates the cAMP/PKA/CREB pathway through ubiquitin E3 ligase activity.

This study synthesizes and evaluates polycyclic amines as alternatives to adamantane in M2 channel inhibitors, identifying compounds effective against wild-type and mutant M2 channels and showing antiviral activity against human coronavirus 229E.

The paper introduces a hybrid machine learning framework that improves protein-ligand interaction prediction by combining biophysicochemical insights with large-scale representations, achieving faster and more accurate virtual screening.

This study shows that non-active site mutations in SARS-CoV-2 Mpro enhance dimer-dimer interactions, aiding substrate binding and resistance to nirmatrelvir.

The paper designs SARS-CoV-2 PLpro inhibitors that show antiviral efficacy in a mouse model against SARS-CoV-2 and its variants.

This study identifies CAMKV kinase signaling as a critical driver of neuroblastoma growth and shows it as a potential therapeutic target and prognostic marker.