Single-cell landscape of nuclear configuration and gene expression during stem cell differentiation and X inactivation
Giancarlo Bonora, Vijay Ramani, Ritambhara Singh…·Christine M. Distèche
The paper integrates single-cell RNA-seq, ATAC-seq, and Hi-C data to study nuclear configuration and gene expression changes during stem cell differentiation and X inactivation, revealing discrete structural changes and delayed chromatin compaction.