BiochemistrybioRxivPreprint
BRD2 bridges TFIID and histone acetylation to promote transcriptional initiation
Bin Zheng, Ruxuan Qiu, Sarah R. Gold…·Ali Shilatifard
This study shows BRD2 promotes transcriptional initiation via bromodomain-dependent binding to acetylated histones and recruits TFIID, while BRD4 mediates elongation through CDK9 recruitment.