S. A. Freeman

Reactive oxygen species suppress phagocyte surveillance by oxidizing cytoskeletal regulators

This study shows that reactive oxygen species (ROS) from IgG-opsonized targets suppress phagocyte surveillance by oxidizing cytoskeletal regulators, leading to cell compaction and podosome disassembly.

Lipid peroxidation increases membrane tension, Piezo1 gating and cation permeability to execute ferroptosis

This study shows that lipid peroxidation during ferroptosis increases membrane tension, activates Piezo1 and TRP channels, and causes cation permeability, leading to cell death.

Endothelial integration of mechanosensory signals by the spectrin cytoskeleton

This study shows that the spectrin cytoskeleton in endothelial cells is essential for sensing and transmitting shear stress to mechanosensors, leading to vasoactive responses.