Pharmacology & ToxicologybioRxiv
Characterization of the Endogenous DAF-12 Ligand and Its Use as an Anthelmintic Agent in Strongyloides stercoralis
Z. Wang, M. C. Cheong, J. Tsien…·D. J. Mangelsdorf
This study identifies {Delta}7-DA as the endogenous ligand for Ss-DAF-12 in Strongyloides stercoralis and shows its potential as a therapeutic target when combined with ivermectin.
DOI 10.7554/elife.73535