H. Deng

The ability of enzymes to preserve reactive conformations with well-positioned residues during enzyme-catalyzed reactions can be an important factor for efficient catalysis: a case study of CARNMT1

This study uses computational simulations to show that preserving reactive conformations with well-positioned residues is critical for catalytic efficiency in CARNMT1, as demonstrated by comparing wild-type and mutant enzymes.

CRMP/UNC-33 maintains neuronal microtubule arrays by promoting individual microtubule rescue

This study shows UNC-33 maintains neuronal microtubule arrays by promoting microtubule rescue, preventing loss and maintaining polarity in C. elegans neurons.

Biodegradation Potential of Neptunomonas naphthovoran - NAG-2N-126 for Crude Oil Pollution Mitigation: Experimental and Modelling Insights

This study evaluates the biodegradation potential of Neptunomonas naphthovoran NAG-2N-126 for crude oil pollution using experimental and mathematical modeling approaches, showing rapid growth and high aromatic compound degradation rates.

Peripheral B Lymphocyte Serves as A Reservoir for The Persistently Covert Infection of Mandarinfish Siniperca chuatsi Ranavirus

This study identifies peripheral B lymphocytes as a viral reservoir for persistent and covert Mandarinfish Ranavirus (MRV) infection, revealing a unique reactivation mechanism distinct from other ranaviruses.

Rbbp8nl contributes to resistance to anticancer immunotherapy by creating a non-inflamed tumor microenvironment and attenuating CD8+ T cell infiltration

This study identifies RBBP8NL as a factor that reduces immune response in tumors by creating a non-inflammatory microenvironment and limiting CD8+ T cell infiltration, suggesting it as a target for improving immunotherapy.

Gamma protocadherins in vascular endothelial cells inhibit Klf2/4 to promote atherosclerosis

This study identifies Pcdhg as a suppressor of Klf2/4 in endothelial cells, promoting atherosclerosis by inhibiting the Notch pathway.

Development of attenuated coxsackievirus B3 vectored intranasal pre-emptive pan-coronavirus vaccine

The paper designs an intranasal pan-coronavirus vaccine using epitopes from SARS-CoV-2 and zoonotic coronaviruses, showing immune responses in mice but needing further cross-reactivity testing.

Paternal genomic resources from the YanHuang cohort suggested a Weakly-Differentiated Multi-source Admixture model for the formation of Hans founding ancestral lineages

The paper analyzes paternal genomic data from the YanHuang cohort to propose a Weakly-Differentiated Multi-source Admixture model for the formation of Han Chinese ancestral lineages.

cSTAR analysis identifies endothelial cell cycle as a key regulator of flow-dependent artery remodeling

The paper uses cSTAR to analyze endothelial cell transcriptomic states under different flow conditions, identifies CDK2 as a key regulator of artery remodeling.

Metabolic Nutrient Preferences of Vibrio mimicus: Leveraging Nucleotides and Oligopeptides from Yellow Catfish for Enhanced Infectivity

This study identifies host-specific metabolites that enhance Vibrio mimicus infectivity in yellow catfish by providing nutrients like deoxyguanosine.

A novel virus-induced cyclic dinucleotide, 2'3'-c-di-GMP, mediates STING-dependent antiviral immunity in Drosophila

A megaprotein brake for aging and insulin-mTOR signaling

This study identifies LPD-3 as a megaprotein that regulates insulin-mTOR signaling and aging in C. elegans by modulating sphingolipid and insulin pathways.

A non-canonical function of LDHB promotes SLC7A11-mediated glutathione metabolism and protects against glutaminolysis-dependent ferroptosis in KRAS-driven lung cancer

This study identifies a non-canonical role of LDHB in protecting KRAS-driven lung cancer from ferroptosis by promoting SLC7A11-mediated glutathione metabolism.

Nimbolide Targets RNF114 to Induce the Trapping of PARP1 and Poly-ADP-Ribosylation-Dependent DNA Repair Factors

This study identifies RNF114 as a key player in PARP1 trapping and shows that nimbolide blocks its degradation, enhancing PARP1 trapping and cytotoxicity in BRCA-deficient cancers.

HOPE-SIM, a cryo-structured illumination fluorescence microscopy system for accurately targeted cryo-electron tomography

The paper introduces HOPE-SIM, a cryo-CLEM system that improves targeting precision for cryo-ET by integrating 3D SIM and software, achieving 150 nm correlation accuracy.

A megaprotein-based molecular bridge critical for lipid trafficking and cold resilience

This paper identifies LPD-3 as a conserved megaprotein critical for lipid trafficking between ER and PM, essential for cold resilience in C. elegans and other species.

Drosophila Keap1 oxidative/xenobiotic response factor interacts with B-type lamin to regulate nuclear lamina and heterochromatin

This study shows that dKeap1 interacts with lamin Dm0 to regulate nuclear lamina and heterochromatin, linking the Keap1-Nrf2 pathway to chromatin structure and developmental transcription.

Extensive neutralization against SARS-CoV-2 variants elicited by Omicron-specific subunit vaccine booster

This study shows that an Omicron-specific subunit vaccine booster enhances neutralizing antibodies against SARS-CoV-2 variants and the ancestral virus, with a two-dose WT-RBD plus Omicron-RBD booster showing the strongest response.

Engineering SARS-CoV-2 cocktail antibodies into a bispecific format improves neutralizing potency and breadth

This study engineers bispecific antibodies against SARS-CoV-2, showing that one design outperforms a cocktail in neutralizing activity and breadth against variants.

Hsa-miR-31-5p controls a metabolic switch in psoriatic keratinocytes that identifies therapeutic intervention

This study shows that miR-31-5p in psoriatic keratinocytes promotes a metabolic switch to glutamine metabolism, leading to immune-modulatory effects and Th17 cell differentiation, which can be inhibited by GLS targeting.

Substrate Specificity for Human Histidine Methyltransferase SETD3

This study investigates the substrate specificity of human SETD3, showing it can methylate histidine and its mimics, with histidine being the most efficient substrate.

Molecular Epidemiology and Microbiological Characteristics of Cryptococcus gattii VGII isolates from China

This study analyzes C. gattii VGII isolates from China using MLST and WGS, revealing genetic diversity and virulence differences, with no drug resistance observed.

Characterization of the Endogenous DAF-12 Ligand and Its Use as an Anthelmintic Agent in Strongyloides stercoralis

This study identifies {Delta}7-DA as the endogenous ligand for Ss-DAF-12 in Strongyloides stercoralis and shows its potential as a therapeutic target when combined with ivermectin.

MEKK3-TGFβ crosstalk regulates inward arterial remodeling

This study identifies endothelial MEKK3 as a regulator of inward arterial remodeling through TGFβ-Smad2/3 signaling, leading to hypertension and atherosclerosis.

Ribosomal protein L23 drives the metastasis of hepatocellular carcinoma via upregulating MMP9

This study identifies ribosomal protein L23 as a driver of hepatocellular carcinoma metastasis by upregulating MMP9 expression and promoting tumor growth and metastasis in vivo.

Lung adenocarcinoma cell-derived exosomal miR-328 promote osteoclastogenesis by targeting Nrp2

This study shows that exosomal miR-328 from lung adenocarcinoma cells promotes osteoclastogenesis by targeting Nrp2 and suggests its inhibitors as a potential treatment for bone metastasis.

ProXs drive the formation of membraneless organelles in plants

The paper identifies ProXs, proteins capable of forming membraneless organelles in plants, and shows their conservation across species.

Artemisinin-based hybrids produce intracellular proteasome inhibitors that overcome resistance in Plasmodium falciparum

This study designs artezomibs, artemisinin-proteasome inhibitor hybrids, which overcome resistance in Plasmodium falciparum by targeting proteasomes, including those with mutations.

Heterogeneity in Proline Hydroxylation of Fibrillar Collagens Observed by Mass Spectrometry

The paper uses mass spectrometry to analyze proline hydroxylation in collagens, finding heterogeneity in hydroxylation patterns across different collagen types and sources.

Phase separation of RNA-binding protein promotes polymerase engagement and transcription

The paper investigates how RNA-binding proteins (RBPs) influence RNA polymerase II activity through phase separation, showing that RBPs like PSPC1 enhance polymerase engagement and transcription.