BiochemistrybioRxiv
Structure and mechanism of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate
S. A. McMahon, W. Zhu, S. Graham…·T. M. Gloster
This paper describes the structure and mechanism of Can1, a cOA-activated CRISPR defence DNA nuclease, showing how cA4 binding activates its DNA nicking activity.
DOI 10.1038/s41467-019-14222-x