Applying Historical Data in a Nonlinear Mixed-Effects Model Can Reduce the Number of Control Rats Required for Calculation of the Relative Potency of Insulin Analogues
E. P. Nielsen, S. Andersen, C. L. Brand, S. Ditlevsen
This paper shows that using historical data in a nonlinear mixed-effects model reduces the number of control rats needed for insulin analogue potency studies by 23-51%.
bioRxiv · Sep 10, 2021Pharmacology & Toxicology