Author

A. Kulasinghe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Assay:spatial transcriptomics· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

J. Monkman· 3 shared C. Cooper· 2 shared A. F. R. d. S. Miggiolaro· 1 shared A. K. Lagendijk· 1 shared A. Pratapa· 1 shared A. Raghubar· 1 shared B. Anand· 1 shared B. Ben Cheikh· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersCancer Biology

J. Monkman

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Author profile →

3 papers

Recent·Most cited

Single-cell Spatial Metabolic and Immune Phenotyping of Head and Neck Cancer Tissues Identifies Tissue Signatures of Response and Resistance to Immunotherapy

N. Jhaveri, B. Ben Cheikh, N. Nikulina, N. Ma, D. Klymyshyn, J. DeRosa, R. Mihani, A. Pratapa, Y. Kassim, S. Bommakanti, O. Shang, Y. He, Y. Zheng, J. Monkman, C. Cooper, , O. Braubach

This study uses single-cell spatial analysis to identify immune and metabolic tumor microenvironment signatures associated with response and resistance to immunotherapy in head and neck cancer.

bioRxiv · May 30, 2023Cancer Biology

Endothelial cells elicit a pro-inflammatory response to SARS-COV-2 without productive viral infection

L. Schimmel, K. Y. Chew, C. Stocks, T. Yordanov, P. Essebier, A. Kulasinghe, J. Monkman, A. F. R. d. S. Miggiolaro, C. Cooper, L. De Noronha, A. K. Lagendijk, K. Schroder, L. Labzin, E. J. Gordon, K. R. Short

This study shows that endothelial cells can be infected by SARS-CoV-2 but do not produce infectious virus, instead triggering an inflammatory response through sensing adjacent infections.

bioRxiv · Feb 14, 2021 · PreprintCell Biology

Spatial analysis of ligand-receptor interaction in skin cancer at genome-wide and single-cell resolution

M. Tran, S. Yoon, M. T. Siok, S. Andersen, P. Lam, B. Purdue, A. Raghubar, S. J. Hanson, K. Devitt, K. Jones, S. Walters, Z. K. Tuong, A. Kulasinghe, J. Monkman, P. H. Soyer, , Q. Nguyen

The paper develops a toolbox to study cancer-immune cell communication using multimodal data and a computational method called STRISH, validated on basal and squamous cell carcinomas.

bioRxiv · Sep 10, 2020Cancer Biology