Cell BiologybioRxiv
SF3B1 promotes tumor malignancy through splicing-independent co-activation of HIF1α
P. Simmler, C. Cortijo, L. M. Koch…·G. Schwank
This study shows SF3B1 promotes tumor malignancy by co-activating HIF1α through a splicing-independent mechanism, enhancing hypoxia response element binding and target gene expression.
DOI 10.1016/j.celrep.2022.111266