Exogenous DNA upregulates DUOX2 expression and function in human pancreatic cancer cells by activating the cGAS-STING signaling pathway
S. L. Wang, Y. Wu, M. Konate, J. Lu, S. Antony, J. L. Meitzler, G. Jiang, I. Dahan, A. Juhasz, B. Diebold, K. Roy, J. H. Doroshow
This study shows exogenous DNA activates the cGAS-STING pathway in pancreatic cancer cells, increasing DUOX2 expression and H2O2 production, which may promote an oxidative microenvironment.
bioRxiv · May 14, 2022 · PreprintCancer Biology