Author

B. Karim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Organism:mouse· 2 Assay:multiome· 2

Frequent Co-Authors

K. Saylor· 3 shared N. Martin· 3 shared P. F. Johnson· 3 shared S. Basu· 3 shared B. Luke· 2 shared J. Salotti· 2 shared S. Lockett· 2 shared S. Misra· 2 shared

Activity by Year

2021-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

K. Saylor

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

CK2 signaling from TOLLIP-dependent perinuclear endosomes is an essential feature of KRAS and NRAS mutant cancers

S. Basu, B. Luke, B. Karim, N. Martin, S. Lockett, S. Das, T. Andresson, K. Saylor, S. Kozlov, L. Bassel, D. Esposito, M. Galloux, P. F. Johnson

This study identifies TOLLIP as a critical adaptor for CK2 signaling from perinuclear endosomes in KRAS and NRAS mutant cancers, showing its role in tumor proliferation and progression.

bioRxiv · Apr 5, 2022 · PreprintCancer Biology

3'UTR-dependent dynamic changes in TP53 mRNA localization regulate p53 tumor suppressor activity

L. Hu, S. Misra, B. Karim, S. Kuhn, J. Salotti, S. Basu, N. Martin, K. Saylor, P. F. Johnson

This study shows that 3'UTR sequences of TP53 mRNA regulate its localization and activity by modulating CK2 phosphorylation and AMPK2/HuR dynamics.

bioRxiv · Apr 4, 2022 · PreprintCancer Biology

3'UTR-directed, kinase proximal mRNA decay inhibits C/EBPβ phosphorylation/activation to suppress senescence in tumor cells

J. Salotti, N. Asif, S. Basu, A. Das, M. Yang, B. Karim, K. Saylor, N. Martin, D. A. Scheiblin, S. Misra, B. Luke, T. Andresson, S. Lockett, L. Tessarollo, P. F. Johnson

This study identifies a mechanism where 3'UTR-directed mRNA decay inhibits C/EBPβ activation, suppressing senescence in tumor cells and promoting tumor progression.

bioRxiv · Mar 29, 2022Cancer Biology

Dexamethasone Inhibits Cytokine-Induced, DUOX2-Related VEGF-A Expression and DNA damage in Human Pancreatic Cancer Cells and Growth of Pancreatic Cancer Xenografts

Y. Wu, M. M. Konate, M. Hollingshead, B. Karim, B. Diebold, J. Lu, S. Antony, J. L. Meitzler, A. Juhasz, G. Jiang, I. Dahan, K. Roy, J. H. Doroshow

This study shows dexamethasone inhibits cytokine-induced DUOX2 and VEGF-A expression and DNA damage in pancreatic cancer cells and xenografts, but not in cytokine-unresponsive cells.

bioRxiv · Feb 13, 2022 · PreprintPharmacology & Toxicology

Whole Organism Profiling of the Timp Gene Family

D. Peeney, Y. Fan, S. Gurung, C. Lazaroff, S. Ratnayake, A. Warner, B. Karim, D. Meerzaman, W. G. Stetler-Stevenson

The paper analyzes Timp gene expression across healthy tissues using single-cell RNA sequencing to identify cell-type-specific patterns and expand on these findings with RNA in-situ hybridization.

bioRxiv · Oct 15, 2021Cell Biology