G. Jiang

The up-regulation of TGF-beta1 by miRNA-132-3p/WT1 is involved in inducing leukemia cells to differentiate into macrophages

This study shows that miRNA-132-3p/WT1/TGF-beta1 axis regulates the differentiation of THP-1 leukemia cells into macrophages.

Single nuclei chromatin accessibility and transcriptomic map of breast tissues of women of diverse genetic ancestry

The paper develops a chromatin accessibility and gene expression atlas of human breast tissues from 92 donors of diverse genetic ancestry, identifying 10 cell types and ancestry-dependent gene expression patterns.

SARS-CoV-2 Omicron infection augments the magnitude and durability of systemic and mucosal immunity in triple-dose CoronaVac recipients

This study examines immune responses in CoronaVac-vaccinated individuals after Omicron infection, showing enhanced antibody and cellular immunity compared to unvaccinated controls.

Label-Free Composition Analysis of Supramolecular Polymer - Nanoparticle Hydrogels by Reversed-Phase Liquid Chromatography Coupled with a Charged Aerosol Detector

This paper develops a label-free RPLC-CAD method to analyze supramolecular hydrogel composition and drug payload, demonstrating its applicability for rheological and release kinetic studies.

MethNet: a robust approach to identify regulatory hubs and their distal targets in cancer

MethNet identifies regulatory hubs and their distal targets in cancer by integrating DNA methylation and gene expression data to uncover cis regulatory elements linked to patient survival.

Enrichment and delivery of target proteins into the cell cytosol via Outer Membrane Vesicles

This study uses E. coli outer membrane vesicles to deliver target proteins into eukaryotic cells with high efficiency and enables direct labeling of proteins within vesicles.

A method for rapid nanobody screening with no bias of the library diversity

This paper introduces a method for rapid nanobody screening that preserves library diversity without subcloning or amplification bias, producing functional nanobodies against DR5 and Pfu DNA polymerase.

Identification and functional validation of human islet microRNAs associated with donor trait

The paper identifies human islet microRNAs associated with donor traits and validates their functional role in telomere length and cellular senescence.

Exogenous DNA upregulates DUOX2 expression and function in human pancreatic cancer cells by activating the cGAS-STING signaling pathway

This study shows exogenous DNA activates the cGAS-STING pathway in pancreatic cancer cells, increasing DUOX2 expression and H2O2 production, which may promote an oxidative microenvironment.

Dexamethasone Inhibits Cytokine-Induced, DUOX2-Related VEGF-A Expression and DNA damage in Human Pancreatic Cancer Cells and Growth of Pancreatic Cancer Xenografts

This study shows dexamethasone inhibits cytokine-induced DUOX2 and VEGF-A expression and DNA damage in pancreatic cancer cells and xenografts, but not in cytokine-unresponsive cells.

Propionate ameliorates diabetes-induced neurological dysfunction through regulating the PI3K/Akt/eNOS signaling pathway

This study shows propionate improves diabetes-induced neurological dysfunction by enhancing cerebral microcirculation, reducing oxidative stress, and activating the PI3K/Akt/eNOS signaling pathway in diabetic mice.

Mechanism of hyperproteinemia-induced blood cell homeostasis imbalance in an animal model

This study investigates how hyperproteinemia disrupts blood cell homeostasis in an invertebrate model, identifying novel signaling pathways and potential biomarkers.

In Vitro efficacy comparison of linezolid, tedizolid, sutezolid and delpazolid against rapid growing Mycobacteria isolated in Beijing, China

This study compares the in vitro efficacy of four oxazolidinones against rapid-growing Mycobacteria isolates from Beijing, finding tedizolid most effective against M. abscessus and delpazolid against M. fortuitum.

The barley mutant multiflorus2.b reveals quantitative genetic variation for new spikelet architecture

This study identifies QTLs for spikelet determinacy and supernumerary spikelet phenotypes in the barley mutant multiflorus2.b, revealing polygenic inheritance.

A human antibody with blocking activity to RBD proteins of multiple SARS-CoV-2 variants including B.1.351 showed potent prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus macaques

A valid protective immune response elicited in rhesus macaques by an inactivated vaccine is capable of defending against SARS-CoV-2 infection

This study shows an inactivated SARS-CoV-2 vaccine induces neutralizing antibodies and CTL responses in rhesus macaques, effectively preventing viral replication and lung inflammation.

The systemic activin response to pancreatic cancer: Implications for effective cancer cachexia therapy

This study shows that pancreatic cancer induces a systemic activin response contributing to cachexia, and that targeting both tumor and host-derived activins may improve therapy.