Y. Wu

Identification of targetable vulnerabilities of PLK1-overexpressing cancers by synthetic dosage lethality

The paper identifies synthetic dosage lethality targets for PLK1-overexpressing cancers using genome-wide screens and validates key hits to show their therapeutic potential.

Biodiversity in mountain soils above the treeline

This paper synthesizes research on biodiversity in mountain soils above the treeline, highlighting gaps in geographic and taxonomic coverage and the need for improved data to support conservation efforts.

The up-regulation of TGF-beta1 by miRNA-132-3p/WT1 is involved in inducing leukemia cells to differentiate into macrophages

This study shows that miRNA-132-3p/WT1/TGF-beta1 axis regulates the differentiation of THP-1 leukemia cells into macrophages.

Spatiotemporal transcriptomic profiling reveals the dynamic immunological landscape of alveolar echinococcosis

This study uses spatiotemporal transcriptomics to analyze immune dynamics in E. multilocularis infected mouse liver, identifying key immune cell roles and shifts in immune strategy during infection.

Identifying Artifacts from Large Library Docking

The paper identifies docking artifacts in large library screens by rescoring top-ranked molecules with orthogonal methods, finding that 39 predicted cheaters failed experimental testing while 57% of plausible actives showed inhibition.

Ongoing genome doubling promotes evolvability and immune dysregulation in ovarian cancer

This study shows that ongoing whole-genome doubling in ovarian cancer promotes cell diversity and immune dysregulation through chromosomal instability and quiescent states.

Association study of Plasmodium falciparum Acetyl-CoA Synthetase Mutations S868G and V949I with antimalarial drugs

This study investigates the association of PfACAS mutations S868G and V949I with antimalarial drug resistance using whole-genome sequencing and CRISPR/Cas9-engineered parasites.

Fluorogenic Aptamer Optimizations on a Massively Parallel Sequencing Platform

This paper optimizes a DNA-based fluorogenic aptamer (D-FAP) using a screening-and-simulation pipeline on a repurposed sequencing platform, achieving improved fluorescence properties.

Characterizing Excretory-Secretory Products Proteome Across Larval Development Stages in Ascaris suum

This study characterizes the excretory-secretory proteome of Ascaris suum larvae across developmental stages to identify potential therapeutic targets for ascariasis prevention.

A vacuolar invertase gene SlVI modulates sugar metabolism and postharvest fruit quality and resistance in tomato

This study investigates the role of the tomato vacuolar invertase gene SlVI in sugar metabolism, fruit quality, and postharvest resistance, finding that its knockout increases sucrose content, firmness, and resistance to Botrytis cinerea.

Calorie Restriction Induces Degeneration of Neurons with Mitochondrial DNA Depletion by Altering ER-Mitochondria Calcium Transfer

This study shows that calorie restriction exacerbates neuronal degeneration in mtDNA-depleted neurons by increasing ER-mitochondria calcium transfer, suggesting CR may not be beneficial for mitochondrial epilepsy.

Local adaptation of both plant and pathogen: an arms-race compromise in switchgrass rust

The paper examines local adaptation between switchgrass and its rust pathogen across North America, finding that both host and parasite can be locally adapted despite varying genetic loci associated with rust severity.

Intracellular growth of Chlamydia trachomatis leads to global histone hypermethylation by impairing demethylation

This study shows that Chlamydia trachomatis infection causes global histone hypermethylation by inhibiting demethylation, leading to altered transcription and affecting infection outcomes.

Acetyl-CoA Synthetase Mutations S868G and V949I Do Not Confer Resistance to Antimalarial Drugs in vitro in Plasmodium falciparum.

This study investigates whether mutations in PfACAS confer antimalarial drug resistance by engineering parasite lines with these mutations and testing their drug susceptibility in vitro.

Post-flowering photoperiod sensitivity of soybean in pod-setting responses

This study shows that soybean pod formation is sensitive to photoperiod, with LD conditions delaying pod formation and SD conditions affecting pistil morphology to influence pod-setting timing.

scRNA-seq revealed the rules for CDR3 length pairing in TCR beta and alpha chains and BCR heavy and light chains in human and mice

This study uses scRNA-seq to analyze CDR3 length pairing rules in TCR and BCR chains across human and mouse cells, revealing species-specific differences and increased plasticity in humans.

Chlamydia-driven ISG15 expression dampens the immune response of epithelial cells independently of ISGylation

This study shows that ISG15 expression in epithelial cells infected with Chlamydia trachomatis reduces inflammation and bacterial load without requiring ISGylation.

Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer

This study identifies PDE1A as a promoter of NSCLC metastasis through interaction with YTHDF2 and activation of the STAT3 pathway.

Cell-Driven Fluid Dynamics: A Physical Model of Active Systemic Circulation

The paper develops a mathematical model that integrates pressure and osmolarity gradients in systemic circulation, showing how cell properties influence transport and vice versa.

Optimizing Peptide Crosslinks for Cell-Responsive Hydrogels

This paper develops and optimizes peptide crosslinks for hydrogels that are specifically degraded by membrane-type proteases, improving cell behavior compared to existing crosslinks.

Mitochondrial Protein Carboxyl-Terminal Alanine-Threonine Tailing Promotes Human Glioblastoma Growth by Regulating Mitochondrial Function

This study identifies msiCAT-tailing of mitochondrial proteins as a mechanism promoting glioblastoma growth by enhancing mitochondrial function and reducing apoptosis.

Improvement in Outcomes and Prevention of Multiple Organ Dysfunction Syndrome After Cardiac Arrest and Successful Cardiopulmonary Resuscitation by Systemic Administration of Bumetanide in Male Mice

This study shows that systemic bumetanide administration after cardiac arrest and CPR improves survival, reduces brain injury, and prevents multiple organ dysfunction in male mice, with LCN2/NGAL identified as a potential biomarker for early neuroprognostication.

Mitochondrial Oxidative Phosphorylation Capacity in Skeletal Muscle Measured by Ultrafast Z-Spectroscopy (UFZ) MRI at 3T

This study evaluates ultrafast Z-spectroscopy MRI with pH correction for measuring mitochondrial oxidative phosphorylation in human skeletal muscle.

Protein S-glutathionylation confers cell resistance to ferroptosis

This study shows that protein S-glutathionylation protects cells from ferroptosis by maintaining ARF6 function and reducing labile iron pools.

mTOR dysregulation induces IL6 and paracrine AT2 cell senescence impeding lung repair in lymphangioleiomyomatosis

This study shows mTOR dysregulation in LAM causes IL6 production and senescence in AT2 cells, impairing lung repair, and suggests targeting IL6 may help.

Evidence that the SARS-CoV-2 S protein undergoes a conformational change at the Golgi Complex that leads to the formation of virus neutralising antibody binding epitopes in the S1 protein subunit.

The study shows that SARS-CoV-2 S protein undergoes a conformational change at the Golgi complex, forming epitopes recognized by virus-neutralizing antibodies in the S1 subunit.

ESCRT recruitment to damaged lysosomes is dependent on the ATG8 E3-like ligases

This study identifies ATG8 E3-like ligases as damage sensors that facilitate ESCRT recruitment to repair lysosomal membranes.

Targeting oncogenic K-Ras mutants with a small-molecule degrader through Nedd4-1

This study develops a small-molecule degrader, XMU-MP-9, that promotes ubiquitination and degradation of K-Ras mutants, including K-RasG12V, by enhancing Nedd4-1 interaction with K-Ras.

Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response

This study shows that fish CDK2 recruits Dtx4 to ubiquitinate and degrade TBK1, reducing IFN expression and enhancing antiviral resistance.

Quantifying and controlling the proteolytic degradation of cell adhesion peptides

This study quantifies non-specific proteolytic degradation of cell adhesion peptides and shows that terminal modifications can reduce degradation in different cell types and matrices.