Pharmacology & ToxicologybioRxiv
Single-agent Foxo1 inhibition normalizes glycemia and induces gut β-like cells in streptozotocin-diabetic mice
Y.-K. Lee, Y. Nie, B. Diaz…·S. Belvedere
This study shows that Foxo1 inhibitors reduce blood glucose and generate gut β-like cells in diabetic mice, suggesting they could be an alternative to insulin.
DOI 10.1016/j.molmet.2022.101618