Author

T. Kitamoto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

D. Accili· 4 shared W. Du· 4 shared B. Diaz· 2 shared H. Watanabe· 2 shared J. Son· 2 shared N. Sultana· 2 shared S. Belvedere· 2 shared T. Kuo· 2 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCell Biology

D. Accili

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Calorie Restriction activates a gastric Notch-FOXO1 pathway to expand Ghrelin cells

W. M. McKimpson, S. Spiegel, M. Mukhanova, M. Kraakman, W. Du, T. Kitamoto, J. Yu, U. Pajvani, D. Accili

This study shows calorie restriction increases gastric ghrelin cells via a Notch-FOXO1 pathway, involving stem cell proliferation and differentiation changes.

bioRxiv · Mar 6, 2023Cell Biology

Single-agent Foxo1 inhibition normalizes glycemia and induces gut β-like cells in streptozotocin-diabetic mice

Y.-K. Lee, Y. Nie, B. Diaz, N. Sultana, T. Kitamoto, W. Du, R. Leibel, D. Accili, S. Belvedere

This study shows that Foxo1 inhibitors reduce blood glucose and generate gut β-like cells in diabetic mice, suggesting they could be an alternative to insulin.

bioRxiv · Mar 26, 2022Pharmacology & Toxicology

Cyb5r3-based mechanism and reversal of secondary failure to sulfonylurea

H. Watanabe, W. Du, J. Son, L. Sui, S.-i. Asahara, I. J. Kurland, T. Kuo, T. Kitamoto, Y. Miyachi, R. de Cabo, D. Accili

This study identifies Cyb5r3 downregulation as a mechanism of sulfonylurea failure and shows that a Cyb5r3 activator can reverse this failure in an animal model.

bioRxiv · Mar 23, 2022 · PreprintPhysiology

Triple Notch/Tgfβ/FoxO1 blockade converts multiple intestinal sub-lineages into β-like cells and lowers glycemia in diabetic animals

W. Du, J. Wang, T. Kuo, L. Wang, W. McKimpson, J. Son, H. Watanabe, T. Kitamoto, L. Yunkyoung, L. Ratner, K. McCune, Y.-W. Chen, B. Grubbs, M. Thornton, J. Fan, , D. Accili

bioRxiv · Mar 21, 2022 · PreprintCell Biology