Molecular BiologybioRxivPreprint
Loss of nephronophthisis-associated nephrocystin-1 impairs DNA damage repair in kidney organoids
Elena Sendino Garví, S. Biermans, Nine V.A.M. Knoers…·Anne Metje van Genderen
This study shows that loss of nephrocystin-1 in kidney organoids impairs DNA repair, increases senescence, and leads to fibrosis, revealing a new role for NPHP1 in DNA damage response.
DOI 10.1101/2025.06.09.658557