Rosalinde Masereeuw

This study shows that loss of nephrocystin-1 in kidney organoids impairs DNA repair, increases senescence, and leads to fibrosis, revealing a new role for NPHP1 in DNA damage response.

This study shows that short chain fatty acids (SCFAs) enhance kidney proximal tubule cell secretory function by upregulating OAT1 and modulating cAMP signaling pathways.

This paper develops a liver organoid-on-a-chip model using hollow fiber membranes to study drug metabolism and transport, showing improved hepatocyte-like maturation and functional drug processing.

This paper develops a KCNJ16-depleted kidney organoid model to study a genetic kidney tubulopathy, showing that statin treatment reduces lipid accumulation and fibrosis.

This study uses CRISPR/Cas9 HITI to repair CTNS in ciPTEC cells, achieving functional cystinosin restoration and reversing the cystinotic phenotype.

This study shows cocaine increases extracellular dopamine and serotonin by depleting storage vesicles in the rat nucleus accumbens, with individual differences in vesicular release affecting behavior and drug intake.