BioengineeringbioRxiv
Combining rational design and continuous evolution on minimalist proteins that target DNA
I. Inamoto, I. Sheoran, S. C. Popa…·J. A. Shin
The paper designs a protein MEF that combines rational design and continuous evolution to improve DNA-binding specificity and stability compared to its predecessor ME47.
DOI 10.1021/acschembio.0c00684