Author

S. C. Smith

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 3 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:Drosophila· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

B. Longdon· 3 shared F. M. Jiggins· 3 shared J. E. McGonigle· 2 shared J. P. Day· 2 shared L. Tagliaferri· 2 shared T. M. Houslay· 2 shared A. Kamacioglu· 1 shared C. J. Breuker· 1 shared

Activity by Year

2016-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersEvolutionary Biology

B. Longdon

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Mammalian orthoreovirus can exit cells in extracellular vesicles

S. C. Smith, E. Krystofiak, K. Ogden

This study shows mammalian orthoreovirus exits cells via extracellular vesicles and free particles, with EVs providing strain- and cell-type-specific protection from neutralization.

bioRxiv · Aug 29, 2023Microbiology

Reovirus RNA recombination is sequence directed and generates internally deleted defective genome segments during passage

S. C. Smith, J. Gribble, J. R. Diller, M. A. Wiebe, T. W. Thoner, M. R. Denison, K. M. Ogden

This study shows reovirus generates internally deleted defective genome segments through sequence-directed recombination during passage, while rotavirus rarely does so.

bioRxiv · Oct 19, 2020Microbiology

Host-pathogen coevolution increases genetic variation in susceptibility to infection

E. M. Duxbury, J. P. Day, D. Maria Vespasiani, Y. Thüringer, I. Tolosana, S. C. Smith, L. Tagliaferri, A. Kamacioglu, I. Lindsley, L. Love, R. Unckless, F. M. Jiggins, B. Longdon

The paper shows that coevolved pathogens increase genetic variation in host susceptibility to infection compared to novel pathogens.

bioRxiv · Nov 26, 2018Evolutionary Biology

Host shifts result in parallel genetic changes when viruses evolve in closely related species

B. Longdon, J. P. Day, J. M. Alves, S. C. Smith, T. M. Houslay, J. E. McGonigle, L. Tagliaferri, F. M. Jiggins

This study shows that viruses evolving in closely related host species undergo parallel genetic changes, suggesting that adaptation to one host may enhance fitness in related hosts.

bioRxiv · Jan 12, 2018Evolutionary Biology

Vertically transmitted rhabdoviruses are found across three insect families and have dynamic interactions with their hosts

B. Longdon, J. Day, N. Schulz, P. T. Leftwich, M. A. de Jong, C. J. Breuker, M. Gibbs, D. J. Obbard, L. Wilfert, S. C. Smith, J. E. McGonigle, T. M. Houslay, L. I. Wright, L. Livraghi, L. C. Evans, , F. M. Jiggins

The paper identifies vertically transmitted rhabdoviruses in three insect species and shows they spread rapidly through host populations with high maternal transmission rates.

bioRxiv · Oct 31, 2016Evolutionary Biology