Pharmacology & ToxicologybioRxiv
Bromodomain and Extraterminal Protein Inhibitor, Apabetalone (RVX-208), Reduces ACE2 Expression and Attenuates SARS-CoV-2 Infection in vitro
D. Gilham, A. L. Smith, L. Fu…·D. El-Gamal
This study shows apabetalone reduces ACE2 and DPP4 expression and inhibits SARS-CoV-2 infection in vitro, suggesting it could be a potential therapeutic for COVID-19.
DOI 10.3390/biomedicines9040437