A. L. Smith

Immunisation of chickens with inactivated and/or infectious H9N2 avian influenza virus leads to differential immune B cell repertoire development

This study examines how different vaccination and infection regimes in chickens affect their H9N2-specific IgM and IgY antibody repertoires, revealing public and private clonal responses.

Iron deficiency causes aspartate-sensitive metabolic and proliferative dysfunction in CD8+ T cells

This study shows iron deficiency impairs CD8+ T cell proliferation and metabolism by disrupting mitochondrial function, but exogenous aspartate can rescue this defect.

Novel spirocyclic dimer, SpiD3, targets chronic lymphocytic leukemia survival pathways with potent preclinical effects

This paper evaluates SpiD3, a novel spirocyclic dimer, showing potent anti-leukemic effects in CLL cells, including resistance to ibrutinib, by targeting NF-κB signaling and the UPR.

A novel triple-action inhibitor targeting B-cell receptor signaling and BRD4 demonstrates preclinical activity in chronic lymphocytic leukemia

This study shows that SRX3305, a triple-action inhibitor targeting BTK, PI3K, and BRD4, reduces CLL cell proliferation, promotes apoptosis, and blocks migration in preclinical models.

High resolution parallel sequencing reveals multi-strain Campylobacter in broiler chicken flocks testing 'negative' by conventional culture methods: implications for control of Campylobacter infection.

This study uses high-resolution sequencing to detect Campylobacter DNA in broiler chicken flocks, revealing its presence even when conventional methods fail, and highlights the diversity of strains in negative samples.

The erythrocyte membrane properties of beta thalassaemia heterozygotes and their consequences for Plasmodium falciparum invasion

This study examines beta thalassaemia heterozygous erythrocytes' properties and their effect on Plasmodium falciparum invasion, finding no overall reduction in invasion efficiency.

Can good broiler flock welfare prevent colonization by Campylobacter?

The paper investigates whether broiler flock welfare metrics affect Campylobacter colonization using logistic regression and Bayesian networks, finding no direct exacerbation but suggesting shared underlying causes.

Bromodomain and Extraterminal Protein Inhibitor, Apabetalone (RVX-208), Reduces ACE2 Expression and Attenuates SARS-CoV-2 Infection in vitro

This study shows apabetalone reduces ACE2 and DPP4 expression and inhibits SARS-CoV-2 infection in vitro, suggesting it could be a potential therapeutic for COVID-19.

Integration, exploration, and analysis of high-dimensional single-cell cytometry data using Spectre

Spectre is an R package for integrating and analyzing high-dimensional cytometry data, supporting flow, mass, and spectral cytometry, as well as scRNA-seq and imaging data.

Alpha globin variation in the long-tailed macaque suggests malaria selection

The paper examines alpha globin variation in long-tailed macaques and finds it correlates with malaria selection, suggesting similar adaptive processes to humans.

T cell competition profoundly reduces the effect of initial precursor frequency on the generation of CD4 T cell memory

The paper shows that T cell competition reduces the impact of initial precursor frequency on memory cell generation during an immune response.

Antigen-specific competitive inhibition of CD4+ T cell recruitment into the primary immune response

The paper investigates how antigen availability and timing affect CD4+ T cell recruitment and response size during the primary immune response.

Deep sequencing reveals Campylobacter in commercial meat chickens less than 8 days old.

The paper uses molecular methods to detect Campylobacter in young chickens, finding that most carry the bacteria before traditional culture methods can detect it.

Comparative analysis of intracellular and extracellular antibiotic resistance gene abundance in anaerobic membrane bioreactor effluent

This study examines how antibiotic exposure affects intracellular and extracellular ARG abundance in AnMBR effluent, finding that exARGs on small plasmids are preferentially taken up.

Engineered Microbes to Sense and Respond to Enterotoxigenic Escherichia coli

This paper engineers non-pathogenic E. coli to detect ETEC using quorum sensing and cellulose encapsulation for environmental monitoring.