Sphingolipid metabolic flow controls phosphoinositide turnover at thetrans Golgi network
S. Capasso, L. Sticco, R. Rizzo, M. Pirozzi, D. Russo, N. Dathan, F. Campelo, J. van Galen, A. Hausser, V. Malhotra, S. Parashuraman, A. Luini, G. D'Angelo
The paper identifies a homeostatic circuit that regulates sphingolipid levels at the trans Golgi network by linking sphingomyelin production to PtdIns(4)P dephosphorylation, which interrupts cholesterol and sphingolipid transport.
bioRxiv · Nov 28, 2016Cell Biology