F. Campelo

Tensing Flipper: Photosensitized manipulation of membrane tension, lipid phase separation and raft protein sorting in biological membranes

This paper discovers that Flipper, a membrane tension probe, can photosensitize singlet oxygen to alter membrane tension and lipid phase separation, enabling optical control of lipid raft formation.

Differential spatial regulation and activation of integrin nanoclusters inside focal adhesions

The paper uses super-resolution microscopy to show that integrin nanoclusters are spatially segregated within focal adhesions, suggesting coordinated activation through adaptor nanoclusters.

Plant plasmodesmata bridges form through ER-driven incomplete cytokinesis

The paper shows the ER stabilizes plasmodesmata during incomplete cytokinesis in plants by preventing fenestrae fusion and forming communication bridges between daughter cells.

Nanoscale imaging reveals the mechanisms of ER-to-Golgi transport via a dynamic tubular-vesicular network

This study uses live-cell imaging to show ER-to-Golgi transport occurs via a dynamic ARF4 tubular-vesicular network connected to the ER and Golgi.

Partitioning to ordered membrane domains regulates the kinetics of secretory traffic

The paper investigates how membrane domains influence secretory traffic kinetics, finding that raft affinity affects Golgi exit rates but not ER exit.

Human genetic adaptation related to cellular zinc homeostasis

This paper identifies directional selection on SLC30A9 haplotypes in Africa and East Asia, showing a gain-of-function variant in ZnT9 linked to mitochondrial metabolism and neuropsychiatric traits.

Actin-regulated Siglec-1 nanoclustering influences HIV-1 capture and virus-containing compartment formation in dendritic cells

This study shows that actin-regulated Siglec-1 nanoclustering in activated dendritic cells enhances HIV-1 capture and trafficking into a single viral-containing compartment.

Sorting of secretory proteins at the trans-Golgi network by human TGN46

This study identifies TGN46 as a receptor for sorting secretory cargo protein PAUF into TGN-to-plasma membrane carriers, showing its lumenal domain is essential for cargo sorting.

Particle flow modulates growth dynamics and nanoscale-arrested growth of transcription factor condensates in living cells

The paper investigates the biophysical properties of transcription factor condensates using single molecule imaging and modeling, revealing that growth dynamics are regulated by particle flow and molecular escaping.

A physical mechanism of TANGO1-mediated bulky cargo export

This paper presents a physical model explaining how TANGO1 stabilizes ER membrane tension to facilitate procollagen export from the ER.

Membrane receptor MerTK is a newly identified transcriptional regulator that associates to chromatin as nanoclusters during human DC differentiation

This study identifies MerTK as a transcriptional regulator in human dendritic cells, showing its nuclear translocation and clustering during differentiation.

TANGO1 membrane helices create a lipid diffusion barrier at curved membranes

The paper shows TANGO1 membrane helices form a lipid diffusion barrier at curved membranes to prevent mixing during secretory cargo transport.

The ER cholesterol sensor SCAP promotes CARTS biogenesis at ER-Golgi contact sites

The paper shows SCAP facilitates CARTS biogenesis at ER-Golgi contact sites by regulating cholesterol and PI4P exchange under cholesterol-fed conditions.

Tricalbin-mediated contact sites control ER curvature to maintain plasma membrane integrity

The paper identifies Tcb proteins as mediators of ER curvature at ER-PM contact sites, facilitating lipid transport to maintain plasma membrane integrity under stress.

Sphingolipid metabolic flow controls phosphoinositide turnover at thetrans Golgi network

The paper identifies a homeostatic circuit that regulates sphingolipid levels at the trans Golgi network by linking sphingomyelin production to PtdIns(4)P dephosphorylation, which interrupts cholesterol and sphingolipid transport.