V. Malhotra

Anti-cancer drug Tamoxifen interferes with Mycobacterium tuberculosis PhoPR mediated signaling and inhibits mycobacterial growth

This study identifies Tamoxifen as an inhibitor of Mycobacterium tuberculosis PhoPR signaling, reducing bacterial growth and disrupting downstream gene expression.

Ser/Thr Phosphorylation of Mycobacterium tuberculosis Type II Rel TA module by Protein Kinase K interferes with toxin neutralization: A novel mode of TA regulation.

This study identifies Ser/Thr phosphorylation by PknK as a novel regulatory mechanism for Type II TA modules in M. tuberculosis, disrupting toxin-antitoxin interactions.

Endoplasmic reticulum exit sites are segregated for secretion based on cargo size

The paper shows that ERES segregate based on cargo size, with bulky cargoes accumulating less at stalled ERES compared to small molecules.

A model for collagen secretion by intercompartmental continuities

The paper proposes a mechanical/entropic ratchet model explaining how procollagen is exported from the ER via TANGO1-dependent tunnels using molecular gradients of pH and HSP47.

Defects in lipid homeostasis reflect the function of TANGO2 in Acyl-CoA metabolism

The paper shows that TANGO2 deficiency disrupts lipid homeostasis by altering acyl-CoA metabolism, leading to increased lipid droplets and reactive oxygen species.

Biphasic release propensity of mucin granules is supervised by TSPAN8

The paper identifies TSPAN8 as a regulator of biphasic mucin release by sequestering syntaxin-2, preventing reserve granule docking and increasing secretion in its absence.

Pla2g12b is Essential for Expansion of Nascent Lipoprotein Particles

The paper identifies Pla2g12b as essential for lipid loading onto nascent triglyceride-rich lipoproteins, showing its role in TRL expansion and its impact on atherosclerosis resistance.

Sorting of secretory proteins at the trans-Golgi network by human TGN46

This study identifies TGN46 as a receptor for sorting secretory cargo protein PAUF into TGN-to-plasma membrane carriers, showing its lumenal domain is essential for cargo sorting.

The ulcerative colitis associated gene FUT8 regulates the quantity and quality of secreted mucins

This study shows that FUT8 regulates mucin secretion and viscoelastic properties, linking its dysfunction to ulcerative colitis pathogenesis.

Building new compartments for unconventional protein secretion from the early and late Golgi membranes

The paper identifies CUPS and TCUPS as compartments involved in unconventional protein secretion, showing their dynamics and relationship to the Golgi during starvation.

Reversing chemorefraction in colorectal cancer cells by controlling mucin secretion

This study shows that reducing mucin secretion in colorectal cancer cells increases their sensitivity to chemotherapy, offering a strategy to overcome chemoresistance.

Global gene-expression analysis reveals the molecular processes underlying ClC-5 loss-of-function in novel Dent Disease 1 cellular models

The paper uses human proximal tubule cell models to study gene expression changes caused by ClC-5 loss-of-function mutations, revealing distinct molecular pathways affected by different mutations.

Palmitoylation of KChIP3 controls baseline mucin secretion

This study shows that palmitoylation of KChIP3 by zDHHC3 or zDHHC4 is required for its recruitment to mucin granules, thereby regulating baseline mucin secretion.

A physical mechanism of TANGO1-mediated bulky cargo export

This paper presents a physical model explaining how TANGO1 stabilizes ER membrane tension to facilitate procollagen export from the ER.

GORASPs link Golgi cisternae laterally to stabilize the rims and prevent vesiculation

This study shows that GORASPs link Golgi cisternae laterally, stabilizing rims and preventing vesiculation in mice.

TANGO1 membrane helices create a lipid diffusion barrier at curved membranes

The paper shows TANGO1 membrane helices form a lipid diffusion barrier at curved membranes to prevent mixing during secretory cargo transport.

Reactive oxygen species (ROS) triggers unconventional secretion of antioxidants and Acb1

The paper shows that starvation induces ROS production, which triggers the unconventional secretion of antioxidants and Acb1, aiding cell regrowth upon nutrient repletion.

New factors for protein transport identified by a genome-wide CRISPRi screen in mammalian cells

The paper identifies two new factors, TTC17 and CCDC157, involved in protein transport through a CRISPRi screen in mammalian cells, showing their roles in Golgi structure and transport carrier fusion.

Sphingolipid metabolic flow controls phosphoinositide turnover at thetrans Golgi network

The paper identifies a homeostatic circuit that regulates sphingolipid levels at the trans Golgi network by linking sphingomyelin production to PtdIns(4)P dephosphorylation, which interrupts cholesterol and sphingolipid transport.