Copper-independent lysosomal localization of the Wilson disease protein ATP7B
S. Maji, M. Pirozzi, R. Ruturaj, R. Pandey, S. Das, T. Ghosh, A. Gupta
This study reveals that ATP7B, the Wilson disease protein, has a copper-independent lysosomal localization in hepatocytes and recycles between TGN and TGN-proximal lysosomes for copper transport.
bioRxiv · Oct 30, 2022 · PreprintCell Biology