Cell BiologybioRxiv
Sphingolipid metabolic flow controls phosphoinositide turnover at thetrans Golgi network
S. Capasso, L. Sticco, R. Rizzo…·G. D'Angelo
The paper identifies a homeostatic circuit that regulates sphingolipid levels at the trans Golgi network by linking sphingomyelin production to PtdIns(4)P dephosphorylation, which interrupts cholesterol and sphingolipid transport.
DOI 10.15252/embj.201696048