ALKBH7 mediates necrosis via rewiring of glyoxal metabolism
C. Kulkarni, S. M. Nadtochiy, L. Kennedy, J. Zhang, S. Chhim, H. Alwaseem, E. Murphy, D. Fu, P. S. Brookes
This study shows ALKBH7 regulates glyoxal metabolism, and its deficiency protects against necrosis and ischemia-reperfusion injury through hormetic signaling involving methylglyoxal stress.
bioRxiv · May 4, 2020Cell Biology