D. Fu

An Unbiased Proteomic Platform for ATE1-based Arginylation Profiling

The paper introduces an unbiased proteomic platform for ATE1-based arginylation profiling, identifying 235 unique arginylation sites in human proteomes.

Mature and migratory dendritic cells promote immune infiltration and response to anti-PD-1 checkpoint blockade in metastatic melanoma

The paper identifies a mature dendritic cell subtype associated with improved immune response and prognosis in melanoma patients treated with anti-PD-1 checkpoint inhibitors.

Assessing drug uptake and response differences in 2D and 3D cellular environments using stimulated Raman scattering microscopy

This study compares drug uptake and response in 2D and 3D cell cultures using SRS microscopy, finding that 3D spheroids show greater drug tolerance despite similar intracellular drug levels.

The Class III peroxidase OsPrx20 is a key regulator of stress response and growth in rice

This study identifies OsPrx20 as a key regulator of stress response and growth in rice, showing its dual role in osmotic stress tolerance and blast resistance.

tRNA modification enzyme-dependent redox homeostasis regulates synapse formation and memory

This study shows ALKBH8 regulates synaptic formation and memory via redox homeostasis in Drosophila by modulating selenoprotein synthesis and oxidative stress.

β-catenin inhibition disrupts the homeostasis of osteogenic/adipogenic differentiation leading to the development of glucocorticoid-induced osteonecrosis of femoral head

This study shows that β-catenin inhibition disrupts osteogenic/adipogenic differentiation in bone marrow mesenchymal cells, contributing to glucocorticoid-induced osteonecrosis of the femoral head.

Rigosertib promotes anti-tumor immunity via autophagic degradation of PD-L1 in colorectal cancer cells

Rigosertib promotes anti-tumor immunity by inducing autophagic degradation of PD-L1 in colorectal cancer cells, enhancing immune response and synergizing with checkpoint inhibitors.

Senescent cells develop PDK4-dependent hypercatabolism and form an acidic microenvironment to drive cancer resistance

This study identifies PDK4-dependent hypercatabolism in senescent cells that creates an acidic microenvironment, promoting cancer resistance and age-related pathologies.

Calpain-mediated proteolysis of vimentin filaments is augmented in Giant Axonal Neuropathy (GAN) fibroblasts exposed to hypotonic stress

This study shows that hypotonic stress increases calpain-mediated vimentin proteolysis in GAN fibroblasts, which is more pronounced than in controls.

Protein and Lipid Mass Concentration Measurement in Tissues by Stimulated Raman Scattering Microscopy

The paper introduces NoRI, a SRS microscopy method to measure protein, lipid, and water concentrations in tissues, showing cell-specific variations and disease-related changes in Alzheimer's models.

Quantitative imaging of intracellular density with ratiometric stimulated Raman scattering microscopy

This paper introduces a technique to measure intracellular density using ratiometric stimulated Raman scattering microscopy and demonstrates its application in different cell types and 3D tumor spheroids.

Non-destructive Chemical Imaging of Bone Tissue for Intraoperative and Diagnostic Applications

This study uses multimodal imaging and machine learning to analyze bone tissue, achieving >90% accuracy in distinguishing cancer-related diagnostic categories.

Twelve-month specific IgG response to SARS-CoV-2 receptor-binding domain among COVID-19 convalescent plasma donors in Wuhan

The study tracks IgG antibody levels against SARS-CoV-2 RBD in convalescent plasma donors over 12 months, showing sustained positivity and gender/age-related differences.

Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball patterned arrays

This study develops Stereo-seq, a high-resolution spatial transcriptomic method, to analyze mouse organogenesis and map developmental disease loci.

CD73 maintains hepatocyte metabolic integrity and mouse liver homeostasis in a sex-dependentmanner

This study shows that CD73 in hepatocytes maintains liver homeostasis and metabolism, with different effects in male and female mice.

SMAD2 promotes myogenin expression and terminal myogenic differentiation.

This study shows SMAD2 promotes terminal myogenic differentiation by enhancing myogenin expression, independent of TGF{beta} signaling.

ALKBH7 mediates necrosis via rewiring of glyoxal metabolism

This study shows ALKBH7 regulates glyoxal metabolism, and its deficiency protects against necrosis and ischemia-reperfusion injury through hormetic signaling involving methylglyoxal stress.

Microbial coexistence through chemical-mediated interactions

This study shows that chemical-mediated interactions, particularly growth-facilitating influences and self-restraint, promote microbial coexistence in communities.

Anamorphic development and extended parental care in a 520 million-year-old stem-group euarthropod from China

This paper describes extended parental care in a 520-million-year-old euarthropod, providing evidence of anamorphic development and the oldest known example of this reproductive strategy in the fossil record.