Gypenosides modulate NCX calcium flux, insulin secretion and cytoprotection in BRIN-BD11 pancreatic β-cells
C. Patibandla, X. Shu, A. M. Shaw, S. Dolan, S. Patterson
This study shows gypenosides protect BRIN-BD11 β-cells from oxidative stress and enhance calcium influx and insulin secretion via NCX reverse mode and a calcium-independent pathway.
bioRxiv · Jan 29, 2021 · PreprintPharmacology & Toxicology