X. Shu

Legacy of warming and cover crops on the response of soil microbial function to repeated drying and rewetting cycles

This study examines how warming and cover crops influence soil microbial function under repeated drying and rewetting cycles, finding that cover crops enhance microbial adaptation to drought.

CRISPR-repressed toxin-antitoxin provides population-level immunity against diverse anti-CRISPR elements

The paper identifies a CRISPR-repressed toxin that provides population-level immunity against diverse anti-CRISPR elements by expelling them through abortive infection-like effects.

Degenerated CRISPRs widely regulate Cas expression to balance immunity and cost

The paper shows degenerated CRISPRs encode regulatory RNAs that autoregulate Cas protein expression, balancing immunity and host fitness costs.

Phase separation of Myc differentially regulates gene transcription

The paper investigates how phase separation of N-myc affects gene transcription and finds that only a small fraction of N-myc-regulated genes are influenced by this process.

Quorum sensing signal autoinducer-2 inhibits sporulation of Bacillus by interacting with RapC and functions across species

This study identifies AI-2 as a quorum sensing signal that inhibits sporulation in Bacillus velezensis SQR9 by interacting with RapC and ComA, revealing a population-level regulatory mechanism.

Responses of Escherichia coli and Listeria monocytogenes to ozone treatment on non-host tomato: Efficacy of intervention and evidence of induced acclimation

This study evaluates ozone treatment effects on E. coli and L. monocytogenes on non-host tomatoes, showing dose-time dependent survival reduction and distinct gene expression responses.

The beneficial rhizobacterium Bacillus velezensis acquires iron from roots via a type VII secretion system for colonization

This study shows that Bacillus velezensis SQR9 uses a type VII secretion system to acquire iron from plant roots, enhancing its colonization.

Mixing crop residues induces a synergistic effect on microbial biomass and an additive effect on soil organic matter priming

This study shows that mixing crop residues increases soil microbial biomass more than individual residues, without enhancing soil organic matter priming.

Legacy effect of constant and diurnally oscillating temperatures on soil respiration and microbial community structure

This study compares soil respiration and microbial community responses under constant vs. diurnally oscillating temperatures, finding that oscillating temperatures increase CO2 flux and alter microbial communities more than constant temperatures.

Cover crop residue diversity enhances microbial activity and biomass with additive effects on microbial structure

This study shows that diverse cover crop residues increase soil microbial activity but not biomass or community structure, suggesting additive benefits for soil functions.

Gypenosides modulate NCX calcium flux, insulin secretion and cytoprotection in BRIN-BD11 pancreatic β-cells

This study shows gypenosides protect BRIN-BD11 β-cells from oxidative stress and enhance calcium influx and insulin secretion via NCX reverse mode and a calcium-independent pathway.

Ethacridine inhibits SARS-CoV-2 by inactivating viral particles in cellular models

This study identifies ethacridine, an FDA-approved antiseptic, as a potent inhibitor of SARS-CoV-2 by inactivating viral particles in cellular models.

Proteasome Regulation by Reversible Tyrosine Phosphorylation at the Membrane

This study identifies a novel mechanism where Src-mediated phosphorylation of Rpt2-Y439 regulates proteasome function at cellular membranes, impacting cancer therapy response.

Effects of gypenosides on enteroendocrine L-cell function and GLP-1 secretion

This study shows gypenosides enhance GLP-1 secretion and antioxidant gene expression in L-cells, suggesting a mechanism for their anti-diabetic effects.

Cytoprotective effects of combination of gypenosides and Costus pictus D.Don extract in BRIN-BD11 β-cells

This study investigates the synergistic cytoprotective effects of gypenosides and Costus pictus extract on BRIN-BD11 β-cells against palmitate and cytokine-induced toxicity.

Cryo-EM structure of C9ORF72-SMCR8-WDR41 reveals the role as a GAP for Rab8a and Rab11a

This paper reports the cryo-EM structure of the C9ORF72-SMCR8-WDR41 complex, revealing its role as a GAP for Rab8a and Rab11a.

Enhancing Intracellular Accumulation and Target Engagement of PROTACs with Reversible Covalent Chemistry

This study discovers that reversible covalent chemistry enhances PROTAC intracellular accumulation and target engagement, leading to improved efficacy.

H. pylori infection inhibits autophagy to aggravate DNA damage by p62-mediated Rad51 ubiquitination

This study shows H. pylori infection inhibits autophagy, leading to DNA damage via p62-mediated Rad51 ubiquitination in gastric cells.

Endothelial pannexin 1 channels control inflammation by regulating intracellular calcium

This study shows that endothelial pannexin 1 channels regulate inflammation by controlling intracellular calcium, which in turn affects IL-1β production and release.