Cell BiologybioRxivPreprint
Mutant Prion Protein Endoggresomes are Hubs for Local Axonal Organelle-Cytoskeletal Remodeling
T. Chaiamarit, A. Verhelle, R. Chassefeyre…·S. E. Encalada
This study identifies mutant PrP endoggresomes as hubs causing cytoskeletal and transport deficits in axons, leading to organelle retention and mitochondrial dysfunction in prionopathies.
DOI 10.1101/2023.03.19.533383