U. Manor

Mitochondria- and ER-associated actin are required for mitochondrial fusion

The paper shows that actin filaments on mitochondria and ER are required for both fission and fusion, with Arp2/3 and INF2 playing distinct roles in fusion.

Mutant Prion Protein Endoggresomes are Hubs for Local Axonal Organelle-Cytoskeletal Remodeling

This study identifies mutant PrP endoggresomes as hubs causing cytoskeletal and transport deficits in axons, leading to organelle retention and mitochondrial dysfunction in prionopathies.

Endosomal removal and disposal of dysfunctional, immunostimulatory mitochondrial DNA

The paper investigates how dysfunctional mitochondrial DNA is removed via an endosomal pathway, showing that defects in mtDNA replication and segregation trigger a fission checkpoint leading to immune activation and eventual disposal through RAB7-containing endosomes.

Long-term NAD+ supplementation prevents the progression of age-related hearing loss in mice

This study shows that long-term NR supplementation prevents age-related hearing loss in mice by restoring NAD+ levels and modulating synaptic and lipid pathways.

Content-aware frame interpolation (CAFI): Deep Learning-based temporal super-resolution for fast bioimaging

This paper introduces two deep learning models for improving temporal resolution in bioimaging by interpolating frames between image pairs, reducing phototoxicity and enabling long-term live-cell imaging.

A nesprin-4/kinesin-1 cargo model for nuclear positioning in cochlear outer hair cells

This study identifies a conserved 4-amino-acid motif in nesprin-4 that mediates its interaction with kinesin-1, essential for nuclear positioning in outer hair cells and hearing.

INF2-mediated actin filament reorganization confers intrinsic resilience to neuronal ischemic injury

This study shows that INF2-mediated actin reorganization in neurons protects against ischemic injury by counteracting swelling-induced cell death.

Single-cell transcriptomics reveals a conserved metaplasia program in pancreatic injury

The paper uses single-cell RNA sequencing to identify a conserved metaplasia program in pancreatic injury, revealing mucin/ductal populations and neoplastic transformation potential.

SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2

This study shows SARS-CoV-2 Spike protein damages endothelial cells by reducing ACE2 expression and impairing mitochondrial function, leading to vascular inflammation.

Tuft cells restrain pancreatic tumorigenesis through paracrine eicosanoid signaling

This study shows that tuft cells suppress pancreatic tumorigenesis by producing anti-inflammatory prostaglandin D2, which inhibits stromal activation, and identifies their protective role in early disease progression.

Induction of pancreatic tumor-selective ferroptosis through modulation of cystine import

The paper shows that targeting cystine import induces ferroptosis in pancreatic tumors, leading to tumor regression and improved survival in a mouse model.

Auxin-induced nanoclustering of membrane signaling complexes underlies cell polarity establishment in Arabidopsis

This study shows auxin induces TMK1 nanoclustering and lipid nanodomains, which, with microtubule feedback, establish cell polarity in Arabidopsis.

Actin chromobody imaging reveals sub-organellar actin dynamics

The paper develops a method to image sub-organellar actin dynamics using fluorescent actin nanobodies and finds ER-associated actin drives organelle fission.

A novel role for Myosin-Va in mitochondrial fission

This paper shows myosin-Va facilitates mitochondrial fission in melanoma cells by interacting with Spire1C and localizing to fission sites, linking it to the Warburg effect.