Cancer BiologybioRxiv
RNF43 truncating mutations mediate a tumour suppressor-to-oncogene switch to drive niche-independent self-renewal in cancer
M. Spit, N. Fenderico, I. Jordens…·M. M. Maurice
This study identifies RNF43 truncating mutations that switch from tumor suppressor to oncogene, enabling niche-independent self-renewal in cancer and resistance to anti-Wnt therapy.
DOI 10.15252/embj.2019103932