A non-canonical metal center drives activity of the Sediminispirochaeta smaragdinae metallo-β- lactamase SPS-1
Z. Cheng, J. VanPelt, A. Bergstrom, C. Bethel, A. Katko, C. Miller, K. Mason, E. Cumming, H. Zhang, R. Kimble, S. Fullington, S. L. Bretz, J. C. Nix, R. A. Bonomo, D. L. Tierney, , M. W. Crowder
This study characterizes the metallo-β-lactamase SPS-1 from Sediminispirochaeta smaragdinae, revealing a novel metal binding site that challenges inhibitor design.
bioRxiv · Jun 2, 2018Biochemistry