C. Miller

Mapping the soil microbiome functions shaping wetland methane emissions

The paper maps soil microbiome functions in wetlands to understand methane emissions by analyzing microbial communities and gene expression across spatial and temporal gradients.

γδ T cells impair airway macrophage differentiation in lung adenocarcinoma

The paper identifies that CD27+ γδ T cells impair the differentiation of tumor-associated macrophages into airway macrophages in lung adenocarcinoma.

Vinculin is Essential For Sustaining Normal Levels of Endogenous Force Transmission at Cell-Cell Contacts

This study identifies vinculin as essential for maintaining high endogenous force transmission at cell-cell contacts, independent of β-catenin.

Elevated peripheral and nervous system inflammation is associated with decreased short-chain fatty acid levels in Zika-virus infected macaques

This study links reduced short-chain fatty acid levels with elevated inflammation in Zika-virus infected macaques, suggesting microbial dysfunction contributes to CNS and systemic inflammation.

ERBB signalling contributes to immune evasion in KRAS-driven lung adenocarcinoma

The paper investigates how ERBB signaling contributes to immune evasion in KRAS-driven lung adenocarcinoma using a novel mouse model and finds that transient ERBB blockade can restore immune surveillance when combined with PD1 blockade.

The consequences of tetraploidy on Caenorhabditis elegans physiology and sensitivity to chemotherapeutics

This study examines the physiological effects and chemotherapeutic sensitivity of tetraploid C. elegans, finding longer worms, shorter lifespan, smaller brood size, and altered reproductive traits.

Effects of structural complexity and water depth on the juvenile blue crab Callinectes sapidus in a simulated salt marsh mesocosm

This study examines how structural complexity and water depth affect juvenile blue crab survival in a simulated salt marsh mesocosm, finding that shoot density increases survival while water depth does not.

Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates

The paper develops AAV vectors with endothelial-specific tropism for brain delivery in rodents and broad tropism in primates, demonstrating their utility in genetic engineering of the blood-brain barrier.

PTEN deficiency exposes a requirement for an ARF GTPase module in integrin-dependent invasion in ovarian cancer.

This study identifies ARF6 as a critical vulnerability in PTEN-deficient ovarian cancer, showing its role in integrin-dependent invasion and its inverse association with patient outcomes.

Arabidopsis transcriptome responses to low water potential using high throughput plate assays

The paper compares transcriptional responses in Arabidopsis to different water potential reduction methods and introduces a high-throughput hard agar assay.

The global anaerobic metabolism regulator fnr is necessary for the degradation of food dyes and drugs by Escherichia coli

This paper shows that the FNR regulator in E. coli is essential for azo bond degradation in the gut, influenced by oxygen and cysteine levels.

Genomic patterns of malignant peripheral nerve sheath tumour (MPNST) evolution correlate with clinical outcome and are detectable in cell-free DNA

This study identifies genomic patterns in MPNST evolution linked to clinical outcomes and shows these patterns are detectable in cell-free DNA.

Active vision during prey-capture in wild marmoset monkeys

This study examines prey-capture in wild marmosets to show how vision guides and corrects motor actions during hunting.

Immunosuppression and Outcomes in Acute Myeloid Leukemia

This study identifies immunosuppressive features in AML cells associated with poor outcomes in patients treated with standard chemotherapy.

Single-cell analysis uncovers differential regulation of lung γδ T cell subsets by the co-inhibitory molecules, PD-1 and TIM-3

This study identifies differential regulation of lung γδ T cell subsets by PD-1 and TIM-3 using single-cell RNA sequencing and flow cytometry.

Genome-wide analysis of focal DNA hypermethylation in IDH-mutant AML samples

This study identifies focal DNA hypermethylation in IDH-mutant AML samples and links it to TET2 and DNMT3A activity, with implications for AML pathogenesis.

Stony Coral Tissue Loss Disease biomarker bacteria identified in corals and overlying waters using a rapid field-based sequencing approach

The paper identifies SCTLD biomarker bacteria in corals and near-coral seawater using a rapid sequencing approach, revealing 25 ASVs enriched in diseased tissue and four exact matches to previously known SCTLD-associated microbes.

Effect of Adolescent Stress on Adult Morphine-Induced Behavioral Sensitization is Dependent Upon Genetic Background

This study investigates how adolescent stress affects adult morphine behavior, finding genetic differences in how C57BL/6J and BALB/cJ mice respond to stress and morphine.

Ly6C defines a subset of memory-like CD27+ γδ T cells with inducible cancer-killing function

The paper identifies two subsets of CD27+ γδ T cells in mice, distinguished by Ly6C expression, with one subset showing memory-like properties and cancer-killing potential.

PYCR1-dependent proline synthesis in cancer-associated fibroblasts is required for the deposition of pro-tumorigenic extracellular matrix

This study identifies PYCR1-dependent proline synthesis in cancer-associated fibroblasts as critical for collagen production and tumor progression, suggesting PYCR1 as a therapeutic target to inhibit pro-tumorigenic extracellular matrix deposition.

Variation in the expression of a transmembrane protein influences cell growth in Arabidopsis thaliana petals by altering auxin availability.

The paper identifies a gene variant affecting petal size in Arabidopsis by altering auxin availability through changes in a membrane protein's expression.

Loss of adipocyte identity through synergistic repression of PPARγ by TGF-β and mechanical stress

The paper shows that TGF-β and mechanical stress together repress PPARγ, causing adipocytes to lose identity and convert into myofibroblasts in a fibrosis model.

Variation in expression of the HECT E3 ligase UPL3modulates LEC2 levels, gene expression, seed sizeand crop yields in Brassica napus.

The paper identifies variation in BnaUPL3.C03 expression that affects LEC2 levels, gene expression, seed size, and crop yields in Brassica napus.

A non-canonical metal center drives activity of the Sediminispirochaeta smaragdinae metallo-β- lactamase SPS-1

This study characterizes the metallo-β-lactamase SPS-1 from Sediminispirochaeta smaragdinae, revealing a novel metal binding site that challenges inhibitor design.

Identification and characterisation of the cryptic Golgi Apparatus in Naegleria gruberi

The paper identifies and characterizes the unstacked Golgi apparatus in Naegleria gruberi, revealing a tubular morphology and providing transcriptomic evidence of Golgi-associated genes.