R. A. Bonomo

This study investigates how {Omega}-loop mutations in PDC-3 β-lactamase affect its active site dynamics and catalytic activity through molecular simulations.

This paper uses deep learning to analyze the co-evolutionary dynamics of L2 β-lactamases and their functional mechanisms.

This study shows that sulopenem combined with cefuroxime or durlobactam synergistically inhibits Mycobacterium abscessus, with BLIs enhancing antibacterial effects.

This study evolves Staphylococcus aureus under vancomycin selection, revealing two distinct adaptive pathways that lead to divergent collateral sensitivity patterns to first-line antibiotics.

This study investigates the structural role of N170 in substrate-assisted deacylation in KPC-2 β-lactamase, revealing its impact on drug binding and catalytic activity.

The paper investigates how gating interactions between loops in the L1 metallo-β-lactamase affect active site conformational changes and identifies key residues critical for enzyme activity.

The paper introduces a low-cost, open-source morbidostat for educational use, validated through bacterial resistance experiments and student engagement.

This paper shows that human serum albumin (HSA) increases Acinetobacter baumannii resistance to cefiderocol by modulating iron uptake and beta-lactam resistance gene expression.

This study analyzes CRAb isolates from US hospitals using WGS, identifying new sub-lineages and resistance patterns, highlighting shifts in CRAb population structure and clinical impact.

The paper shows that human serum and its components increase Acinetobacter baumannii resistance to cefiderocol by altering iron uptake and beta-lactam resistance genes.

This study shows that human serum albumin and meropenem together enhance natural transformation and gene expression in Acinetobacter baumannii, potentially promoting resistance and evolution.

This study tracks the long-term evolution of antibiotic-resistant Pseudomonas aeruginosa in a cystic fibrosis patient, revealing diverse genetic changes that enhance resistance to multiple cephalosporins.

This study shows that cerebrospinal fluid (CSF) enhances virulence factor expression and metabolic processes in low-virulence Acinetobacter baumannii strains.

This study identifies allosteric communication pathways in Class A β-lactamases using molecular dynamics simulations, showing how amino acid substitutions affect enzyme activity and antibiotic resistance.

This study shows H-NS alleviates envelope stress from MBL expression and DNA-damaging agents in A. baumannii, linking it to stress response and carbapenem resistance.

This study characterizes the metallo-β-lactamase SPS-1 from Sediminispirochaeta smaragdinae, revealing a novel metal binding site that challenges inhibitor design.

This study shows that natural transformation enables Acinetobacter baumannii to acquire antibiotic resistance genes from Klebsiella pneumoniae, contributing to the emergence of multi-drug-resistant strains.