Sprouty2 limits intestinal tuft and goblet cell numbers through GSK3β-mediated restriction of epithelial IL-33.
M. A. Schumacher, J. J. Hsieh, C. Y. Liu, K. L. Appel, A. Waddell, D. Almohazey, K. Katada, J. K. Bernard, E. B. Bucar, S. Gadeock, K. M. Maselli, M. K. Washington, T. C. Grikscheit, D. Warburton, M. J. Rosen, M. R. Frey
This study shows that Sprouty2 restricts intestinal tuft and goblet cell numbers via GSK3β-mediated IL-33 expression, with implications for inflammatory bowel disease.
bioRxiv · Mar 9, 2020Physiology