Nucleic acid receptor ligands improve vaccination efficacy against the filarial nematode Litomosoides sigmodontis
J. F. Scheunemann, F. Risch, J. J. Reichwald, B. Lenz, A.-L. Neumann, S. Garbe, S. J. Frohberger, M. Koschel, J. Ajendra, M. Rothe, E. Latz, C. Coch, G. Hartmann, B. Schumak, A. Hoerauf, M. P. Hübner
This study shows that adding nucleic acid receptor agonists to a vaccine against the filarial nematode Litomosoides sigmodontis improves immune response and reduces worm burden by 73%.
bioRxiv · Jul 11, 2022 · PreprintImmunology