Author

J. Ajendra

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 6 Organism:mouse· 6 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

J. E. Allen· 4 shared B. H. Chan· 3 shared J. Parkinson· 3 shared T. E. Sutherland· 3 shared A. Chenery· 2 shared A. Hoerauf· 2 shared B. Lenz· 2 shared F. Risch· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersImmunology

J. E. Allen

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6 papers

Recent·Most cited

Eosinophils are an endogenous source of IL-4 during filarial infections and contribute to the development of an optimal T helper 2 response

C. Guth, P. P. Schumacher, A. Vijayakumar, H. Borgmann, H. Balles, M. Koschel, F. Risch, B. Lenz, A. Hoerauf, M. P. Hubner, J. Ajendra

This study identifies eosinophils as a major source of IL-4 during filarial infections, showing their critical role in driving Th2 responses without affecting macrophage polarization or antibody production.

bioRxiv · Oct 26, 2023Immunology

IL-17A promotes epithelial cell IL-33 production during nematode lung migration

J. Ajendra, S. Pearson, J. Parkinson, B. H. K. Chan, H. J. McSorley, T. E. Sutherland, J. E. Allen

This study shows IL-17A promotes IL-33 production in lung epithelial cells during nematode infection, independent of IFN-gamma suppression.

bioRxiv · Nov 3, 2022 · PreprintImmunology

Nucleic acid receptor ligands improve vaccination efficacy against the filarial nematode Litomosoides sigmodontis

J. F. Scheunemann, F. Risch, J. J. Reichwald, B. Lenz, A.-L. Neumann, S. Garbe, S. J. Frohberger, M. Koschel, J. Ajendra, M. Rothe, E. Latz, C. Coch, G. Hartmann, B. Schumak, A. Hoerauf, M. P. Hübner

This study shows that adding nucleic acid receptor agonists to a vaccine against the filarial nematode Litomosoides sigmodontis improves immune response and reduces worm burden by 73%.

bioRxiv · Jul 11, 2022 · PreprintImmunology

Genotype and Th2 cells control monocyte to tissue resident macrophage differentiation during nematode infection of the pleural cavity

C. M. Finlay, J. Parkinson, B. H. Chan, J. Ajendra, A. Chenery, A. Morrison, E. L. Houlder, S. M. Baker, B. Dickie, L. Boon, A. S. MacDonald, J. E. Konkel, D. Rückerl, J. E. Allen

This study shows that host genetics and Th2 cells influence monocyte-to-tissue-resident-macrophage differentiation during nematode infection in mice.

bioRxiv · Dec 17, 2021 · PreprintImmunology

IL-17A both initiates (via IFNγ suppression) and limits the pulmonary type 2 immune response to nematode infection

J. Ajendra, A. L. Chenery, J. E. Parkinson, B. H. Chan, S. Pearson, S. A. Colombo, L. Boon, R. K. Grencis, T. E. Sutherland, J. E. Allen

This study shows IL-17A suppresses IFNγ to initiate and later limits type-2 immune responses in the lung during nematode infection.

bioRxiv · Apr 18, 2020Immunology

Inflammasome-independent role for NLRP3 in controlling innate anti-helminth immunity and tissue repair in the lung

A. Chenery, R. Alhallaf, Z. Agha, J. Ajendra, J. Parkinson, M. M. Cooper, B. H. Chan, R. M. Eichenberger, L. A. Dent, A. A. Robertson, A. Kupz, D. Brough, A. Loukas, T. E. Sutherland, J. E. Allen, P. Giacomin

This study shows NLRP3 limits lung neutrophilia and helminth killing in an inflammasome-independent way, while promoting tissue repair.

bioRxiv · Jun 7, 2019Immunology