Genomic instability is an early event driving chromatin reorganization and escape from oncogene-induced senescence
C. Zampetidis, P. Galanos, A. Angelopoulou, Y. Zhu, T. Karamitros, N. Lagopati, R. Mirzazadeh, A. Polyzos, S. Garnerone, E. G. Gusmao, K. Sofiadis, D. E. Pefani, M. Demaria, N. Crosetto, A. Maya-Mendoza, , V. G. Gorgoulis
The paper identifies an early chromosomal inversion that enables escape from oncogene-induced senescence by activating BHLHE40 and promoting malignant transformation.
bioRxiv · Dec 20, 2020Cell Biology