Cell BiologybioRxiv
Genomic instability is an early event driving chromatin reorganization and escape from oncogene-induced senescence
C. Zampetidis, P. Galanos, A. Angelopoulou…·V. G. Gorgoulis
The paper identifies an early chromosomal inversion that enables escape from oncogene-induced senescence by activating BHLHE40 and promoting malignant transformation.
DOI 10.1016/j.molcel.2021.10.017