Author

S. Gruschow

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Assay:proteomics· 3 Organism:bacteria (other)· 2 Assay:metagenomics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Organism:E. coli· 1

Frequent Co-Authors

M. F. White· 4 shared S. Graham· 2 shared S. McMahon· 2 shared B. Bode· 1 shared C. S. Adamson· 1 shared C. Zhang· 1 shared H. Chi· 1 shared J. S. Athukoralage· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersMicrobiology

M. F. White

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

CRISPR antiphage defence mediated by the cyclic nucleotide-binding membrane protein Csx23

S. Gruschow, S. McQuarrie, K. Ackermann, S. McMahon, B. Bode, T. M. Gloster, M. F. White

This study identifies Csx23 as a CRISPR effector that uses cyclic nucleotide binding to mediate antiphage defence in Vibrio cholerae.

bioRxiv · Nov 24, 2023Microbiology

Antiviral Type III CRISPR signalling via conjugation of ATP and AdoMet

H. Chi, V. Hoikkala, S. Gruschow, S. Graham, S. Shirran, M. F. White

This study identifies SAM-AMP as a novel second messenger in type III-B CRISPR systems, used for antiviral signaling by conjugating ATP to S-adenosyl methionine.

bioRxiv · Jun 26, 2023 · PreprintMicrobiology

Specificity and sensitivity of an RNA targeting type III CRISPR complex coupled with a NucC endonuclease effector

S. Gruschow, C. S. Adamson, M. F. White

This study characterizes the VmeCmr type III CRISPR system's RNA targeting specificity and sensitivity, demonstrating its potential as a highly specific and sensitive assay for SARS-CoV-2 RNA detection.

bioRxiv · Sep 13, 2021Biochemistry

A viral ring nuclease anti-CRISPR subverts type III CRISPR immunity

J. S. Athukoralage, S. McMahon, C. Zhang, S. Gruschow, S. Graham, M. Krupovic, R. J. Whitaker, T. Gloster, M. F. White

This study identifies a viral anti-CRISPR enzyme that degrades cyclic tetra-adenylate, neutralizing type III CRISPR immunity in bacteria and archaea.

bioRxiv · Sep 24, 2019Biochemistry