Cell BiologybioRxiv
Allosteric inhibition of the epidermal growth factor receptor through disruption of transmembrane interactions
J. A. Rybak, A. R. Sahoo, S. Kim…·F. N. Barrera
This study develops a pH-responsive peptide, PET1, that inhibits EGFR-mediated cell migration by disrupting transmembrane interactions, offering a new strategy for targeting RTKs with reduced side effects.
DOI 10.1016/j.jbc.2023.104914