Author

A. W. Smith

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 4 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

M. Buck· 4 shared S. Kim· 3 shared X. Shi· 3 shared B. Wang· 2 shared L. H. Chao· 2 shared R. Lingerak· 2 shared Y. Ge· 2 shared A. L. Hartzler· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersBiophysics

M. Buck

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The SAM Domain of EphA2 Inhibits Ligand-Independent Clustering and Activation

X. Shi, R. Lingerak, P. Shrestha, M. Buck, B. Wang, A. W. Smith

This study investigates the role of the SAM domain in EphA2, showing it inhibits ligand-independent clustering and kinase activity in both full-length and intracellular domain constructs.

bioRxiv · Oct 5, 2023 · PreprintBiophysics

Allosteric inhibition of the epidermal growth factor receptor through disruption of transmembrane interactions

J. A. Rybak, A. R. Sahoo, S. Kim, R. J. Pyron, S. B. Pitts, S. Guleryuz, A. W. Smith, M. Buck, F. N. Barrera

This study develops a pH-responsive peptide, PET1, that inhibits EGFR-mediated cell migration by disrupting transmembrane interactions, offering a new strategy for targeting RTKs with reduced side effects.

bioRxiv · Oct 31, 2022Cell Biology

Allele-specific activation, enzyme kinetics, and inhibitor sensitivities of EGFR exon 19 deletion mutations in lung cancer

B. P. Brown, Y. Zhang, S. Kim, P. Finneran, Y. Yan, Z. Du, J. Kim, A. L. Hartzler, M. L. LeNoue-Newton, A. W. Smith, J. Meiler, C. M. Lovly

The paper identifies allele-specific functional differences among EGFR exon 19 deletion variants, showing how sequence and structure motifs affect oncogenic activity, dimerization, and TKI sensitivity.

bioRxiv · Mar 16, 2022Cancer Biology

Cell Surface Multimeric Assemblies Regulate Canonical and Noncanonical EphA2 Receptor Tyrosine Kinase Signaling

X. Shi, R. Lingerak, C. Herting, Y. Ge, S. Kim, P. Toth, C. Cuizon, J. Zheng, L. H. Chao, K. Sossey-Alaoui, M. Buck, S. Singh, V. Varadan, J. Himanen, D. Hambardzumyan, , B. Wang

This study identifies molecular interfaces that mediate EphA2 receptor assembly and distinguishes between canonical and noncanonical signaling pathways.

bioRxiv · Apr 11, 2021 · PreprintBiophysics

Resolving the Interactions Between Class 3 Semaphorin Receptors in Live Cells

S. M. Christie, J. Hao, E. Tracy, M. Buck, J. S. Yu, A. W. Smith

This study uses PIE-FCCS to analyze receptor interactions in live cells, finding that Plexin D1 is monomeric while others form dimers or heteromers, with ligand-induced complex formation only observed for Plexin D1 and neuropilin-1.

bioRxiv · Feb 18, 2021 · PreprintBiophysics

Two forms of Opa1 cooperate to complete fusion of the mitochondrial inner-membrane

Y. Ge, X. Shi, S. Boopathy, J. McDonald, A. W. Smith, L. H. Chao

The paper shows that two forms of Opa1 work together to regulate mitochondrial inner-membrane fusion, with l-Opa1 enabling docking and s-Opa1 facilitating efficient pore opening.

bioRxiv · Dec 11, 2019Biophysics