Coordination of di-acetylated histone ligands by the ATAD2 bromodomain
C. M. Evans, M. Phillips, K. L. Malone, M. Tonelli, G. Cornilescu, C. Cornilescu, S. Holton, M. Gorjanacz, L. Wang, S. Carlson, J. C. Gay, J. C. Nix, B. Demeler, J. L. Markley, K. C. Glass
This study identifies how the ATAD2 bromodomain recognizes di-acetylated histone tails through residue-specific interactions and confirms its monomeric state using biophysical techniques.
bioRxiv · Jul 23, 2021Biochemistry