Author

J. L. Markley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 3 Research Focus:chromatin & epigenetic regulation· 3 Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

C. M. Evans· 3 shared G. Cornilescu· 3 shared K. C. Glass· 3 shared M. Phillips· 3 shared B. Demeler· 2 shared J. C. Gay· 2 shared M. Tonelli· 2 shared M. Y. Lubula· 2 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

C. M. Evans

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Coordination of di-acetylated histone ligands by the ATAD2 bromodomain

C. M. Evans, M. Phillips, K. L. Malone, M. Tonelli, G. Cornilescu, C. Cornilescu, S. Holton, M. Gorjanacz, L. Wang, S. Carlson, J. C. Gay, J. C. Nix, B. Demeler, J. L. Markley, K. C. Glass

This study identifies how the ATAD2 bromodomain recognizes di-acetylated histone tails through residue-specific interactions and confirms its monomeric state using biophysical techniques.

bioRxiv · Jul 23, 2021Biochemistry

Structural insights into the recognition of mono- and di-acetylated histones by the ATAD2B bromodomain

J. T. Lloyd, K. McLaughlin, M. Y. Lubula, J. C. Gay, A. Dest, C. Gao, M. Phillips, M. Tonelli, G. Cornilescu, M. R. Marunde, C. M. Evans, S. P. Boyson, S. Carlson, M.-C. Keogh, J. L. Markley, , K. C. Glass

This study investigates the ligand specificity of the ATAD2B bromodomain, showing it binds mono- and di-acetylated histones and identifies structural features critical for this recognition.

bioRxiv · May 12, 2020 · PreprintBiochemistry

The BRPF1 bromodomain is a molecular reader of di-acetyllysine

J. O. Obi, M. Y. Lubula, G. Cornilescu, A. Henrickson, K. McGuire, C. M. Evans, M. Phillips, S. P. Boyson, B. Demeler, J. L. Markley, K. C. Glass

This study identifies the BRPF1 bromodomain as a selective reader of di-acetyllysine modifications on histone H4 and characterizes its binding preferences and mechanisms.

bioRxiv · Feb 13, 2020Biochemistry

Inhibition of mitochondrial ferredoxin 1 (FDX1) prevents adaptation to proteotoxic stress

P. Tsvetkov, A. Detappe, K. Cai, H. R. Keys, Z. Brune, W. Ying, P. Thiru, M. Reidy, G. Kugener, A. Tsherniak, S. Santagata, L. Whitesell, J. L. Markley, I. M. Ghobrial, S. Lindquist

This study identifies FDX1 inhibition as a strategy to prevent proteasome inhibitor resistance in cancer by targeting mitochondrial Fe-S cluster biosynthesis.

bioRxiv · Mar 24, 2018Cancer Biology