High-throughput screening of the ReFRAME, Pandemic Box, and COVID Box drug repurposing libraries against SARS-CoV2 nsp15 endoribonuclease to identify small-molecule inhibitors of viral activity.
R. Choi, M. Zhou, R. Shek, J. W. Wilson, L. Tillery, J. K. Craig, I. A. Salukhe, S. E. Hickson, N. Kumar, R. M. James, G. W. Buchko, R. Wu, S. Huff, T.-T. Nguyen, B. L. Hurst, , W. C. Van Voorhis
The paper screens drug libraries to find inhibitors of SARS-CoV-2 nsp15 endoribonuclease, identifying Exebryl-1 as a potential antiviral compound.
bioRxiv · Jan 21, 2021Microbiology