Author

R. Choi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Microbiology· 2 Cancer Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

L. K. Barrett· 3 shared K. K. Ojo· 2 shared L. Santhanam· 2 shared W. C. Van Voorhis· 2 shared A. Hemphill· 1 shared A.-L. B. G. Vigil· 1 shared B. G. K. Perera· 1 shared B. L. Hurst· 1 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersCancer Biology

L. K. Barrett

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Sex Differences and Role of Lysyl Oxidase Like 2 (LOXL2) in Angiotensin II-Induced Hypertension in Mice

L. Santhanam, H. Wang, M. M. Yus, T. Brady, R. Choi, K. Nandakumar, L. Smith, R. Jang, B. P. Wodu, J. D. Almodiel, L. Stoddart, D.-H. Kim, J. Steppan

This study investigates sex differences and the role of LOXL2 in Ang II-induced hypertension, finding that LOXL2 depletion protects males but worsens female aortic contractility.

bioRxiv · Dec 13, 2023Physiology

A Compound that Inhibits Glycolysis in Prostate Cancer Controls Growth of Advanced Prostate Cancer

T. Uo, K. K. Ojo, C. C. Sprenger, K. S. Epilepsia, B. G. K. Perera, M. Damodarasamy, S. Sun, S. Kim, H. H. Hogan, M. A. Hulverson, R. Choi, G. R. Whitman, L. K. Barrett, S. A. Michaels, L. H. Xu, , S. R. Plymate

This paper evaluates a novel antiglycolytic compound, BKIDC-1553, showing selective growth inhibition of prostate cancer cells and safety for clinical trials.

bioRxiv · Jul 1, 2023Cancer Biology

An Enterobacteriaceae bloom in aging animals is restrained by the gut microbiome

R. Choi, R. Bodkhe, B. Pees, D. J. Kim, M. Berg, D. Monnin, J. Cho, V. Narayan, E. Deller, M. Shapira

The paper identifies an Enterobacteriaceae bloom in aging animals as a common feature, showing its link to immune decline and susceptibility to infection, while highlighting the role of commensal competition in healthy aging.

bioRxiv · Jun 13, 2023 · PreprintPhysiology

Regulation of coronavirus nsp15 cleavage specificity by RNA structure

I. Salukhe, R. Choi, W. V. Voorhis, L. Barrett, J. L. Hyde

This study investigates how RNA secondary structure influences SARS-CoV-2 nsp15 endonuclease cleavage specificity, showing that stable structures protect RNA from cleavage and that uridine positioning within a pentaloop affects cleavage efficiency.

bioRxiv · May 12, 2023Microbiology

An evolutionarily conserved olfactory receptor is required for sex differences in blood pressure

J. Xu, R. Choi, K. Gupta, H. R. Warren, L. Santhanam, J. L. Pluznick

This study identifies Olfr558/OR51E1 as an evolutionarily conserved receptor mediating sex differences in blood pressure through effects on renin, vascular reactivity, and arterial stiffness.

bioRxiv · Nov 16, 2022Physiology

High-throughput screening of the ReFRAME, Pandemic Box, and COVID Box drug repurposing libraries against SARS-CoV2 nsp15 endoribonuclease to identify small-molecule inhibitors of viral activity.

R. Choi, M. Zhou, R. Shek, J. W. Wilson, L. Tillery, J. K. Craig, I. A. Salukhe, S. E. Hickson, N. Kumar, R. M. James, G. W. Buchko, R. Wu, S. Huff, T.-T. Nguyen, B. L. Hurst, , W. C. Van Voorhis

The paper screens drug libraries to find inhibitors of SARS-CoV-2 nsp15 endoribonuclease, identifying Exebryl-1 as a potential antiviral compound.

bioRxiv · Jan 21, 2021Microbiology

Comparative assessment of the effects of bumped kinase inhibitors on early zebrafish embryo development and pregnancy in mice.

N. Anghel, P. A. Winzer, D. Imhof, J. Mueller, X. Langa Oliva, J. Rieder, L. K. Barrett, R. S. R. V. Rao Vidadala, W. Huang, R. Choi, M. Hulverson, G. Whitman, S. Arnold, W. Van Voorhis, K. K. Ojo, , A. Hemphill

This study evaluates the effects of 15 bumped kinase inhibitors on zebrafish embryo development and mouse pregnancy, finding limited predictive value of zebrafish tests for pregnancy outcomes.

bioRxiv · Jun 17, 2020Pathology