R. Wu

Vesicle-mediated mitochondrial clearance underlies an actionable metabolic vulnerability in triple-negative breast cancer

The paper identifies a metabolic vulnerability in triple-negative breast cancer through sphingolipid metabolism, showing that targeting this pathway with eliglustat reduces tumor growth and improves survival.

Environmental and Historical Determinants of African Horse Sickness: Insights from Predictive Modeling

This study uses predictive modeling to analyze global patterns of African Horse Sickness, identifying high-risk areas and highlighting the impact of climate on disease transmission.

Characterization, structure and inhibition of the human succinyl-CoA:glutarate-CoA transferase, a genetic modifier of glutaric aciduria type 1

The paper characterizes the human SUGCT enzyme, determines its structure, and identifies inhibitors that may lead to new treatments for glutaric aciduria type 1.

Parallel Molecular Data Storage by Printing Epigenetic Bits on DNA

This paper introduces a DNA-based data storage method using epigenetic modifications, achieving scalable and parallel data writing and retrieval.

Linking root-associated fungal and bacterial functions to root economics

The paper links fungal and bacterial functions in root-associated communities to root economics traits in a subtropical forest.

Chaperone-mediated autophagy is an overlooked pathway for mutant alpha-1 antitrypsin Z degradation

This study identifies chaperone-mediated autophagy (CMA) as a key pathway for degrading mutant alpha-1 antitrypsin Z (ATZ), showing that enhancing CMA reduces ATZ accumulation in AATD.

Attila and Aetius on the roof: The succession phenomenon in the roof greening area of a primary school in Beijing during the lockdown period of the COVID-19

The paper examines changes in rooftop green areas of a primary school in Beijing before and during the COVID-19 lockdown, focusing on invasive weed succession and its impact on cultivated plants.

Genomic fingerprints of the world's soil ecosystems

This paper analyzes 1512 soil metagenomes to uncover genomic patterns of soil microbiomes across environmental factors and biomes, revealing shifts in microbial functions and biogeographical distributions.

A global atlas of soil viruses reveals unexplored biodiversity and potential biogeochemical impacts

The paper compiles a global soil virus dataset to assess biodiversity and biogeochemical impacts, finding most viral diversity remains unexplored and viruses may influence carbon and nutrient cycling.

Integrated spatial transcriptomics and lipidomics of precursor lesions of pancreatic cancer identifies enrichment of long chain sulfatide biosynthesis as an early metabolic alteration

In vivo Ontogeny of human forebrain neural progenitor cell grafts in adult rats: an immunohistological study

This study tracks human neural progenitor cell grafts in adult rats up to 9 months, revealing their migration and differentiation patterns, and highlights their potential for neural repair.

Endothelial cells secrete small extracellular vesicles bidirectionally containing distinct cargo to uniquely reprogram vascular cells in the circulation and vessel wall

This study shows endothelial cells release distinct extracellular vesicles to reprogram monocytes and smooth muscle cells in circulation and vessel wall.

Multiplexed Sequential Imaging in Living Cells with Orthogonal Fluorogenic RNA Aptamer/Dye Pairs

This paper introduces seqFRIES, a method for multiplexed live-cell imaging using orthogonal RNA aptamer/dye pairs, achieving four-color imaging in ~20 minutes.

Targeted RNA Condensation in Living Cells via Genetically Encodable Triplet Repeat Tags

This study introduces a genetically encoded RNA tag to program RNA condensate formation and modulate RNA localization and function in living cells.

The immune receptor SNC1 monitors helper NLRs targeted by a bacterial effector

The paper shows that SNC1, an immune receptor, guards ADR1-L1 and ADR1-L2 from bacterial effector suppression, enabling plant immunity through sequence diversification and a layered defense system.

A Novel ARNT-Dependent HIF-2α Signaling as a Protective Mechanism for Cardiac Microvascular Barrier Integrity and Heart Function Post-Myocardial Infarction

This study identifies HIF2/ARNT as a protective axis in cardiac endothelial cells post-MI, preventing vascular leakage and inflammation through suppression of IL6.

Ulinastatin Ameliorates Cardiac Ischemia/Reperfusion Injury via Inhibiting the tissue kallikrein-kinin system

This study shows ulinastatin reduces cardiac ischemia/reperfusion injury by inhibiting the tissue kallikrein-kinin system and its downstream signaling pathways.

Cdkn2a regulates beige fat maintenance through BECN1-mediated autophagy

This study shows that Cdkn2a regulates beige fat maintenance via BECN1-mediated autophagy, with implications for obesity and diabetes treatment.

Genetically Encoded RNA-based Bioluminescence Resonance Energy Transfer (BRET) Sensors

This paper introduces genetically encoded RNA-based BRET sensors for real-time target detection in living cells, using a luciferase donor and RNA-based acceptor.

WDFY4 deficiency in NOD mice abrogates autoimmune diabetes and insulitis

This study shows that WDFY4 deficiency in NOD mice prevents autoimmune diabetes by blocking CD8 T cell priming, while preserving CD4 T cell activation and islet infiltration.

Identification of two bZIP transcription factors that regulate development of pavement and trichome cells in Arabidopsis thaliana by single-cell RNA-sequencing

This study identifies bZIP25 and bZIP53 as transcription factors regulating pavement and trichome cell development in Arabidopsis thaliana using single-cell RNA-sequencing.

The production of diverse brGDGTs by an Acidobacterium allows a direct test of temperature and pH controls on their distribution

This paper identifies an Acidobacterium that produces diverse brGDGTs and shows temperature primarily controls C5-methylation while cyclization is influenced by multiple factors.

Disentangling leaf-microbiome interactions in Arabidopsis thaliana by network mapping

This paper uses network mapping to identify plant genes and SNPs that influence microbial network architecture in Arabidopsis thaliana, revealing genetic control of microbial interactions and their impact on plant traits.

Development and characterization of a human arteriovenous malformation (AVM)-on-a-chip model

This study develops an AVM-on-a-chip model using KRAS-mutant endothelial cells to replicate AVM structural and functional features and test drug responses.

Geminivirus C4 proteins inhibit GA signaling via prevention of NbGAI degradation, to promote viral infection and symptom development in N. benthamiana

BCL6-dependent TCF-1+ progenitor cells maintain effector and helper CD4 T cell responses to persistent antigen

Pharmacologic and genetic inhibition of cholesterol esterification reduces tumour burden: a pan-cancer systematic review and meta-analysis of preclinical models

This paper reviews preclinical studies showing that inhibiting cholesterol esterification reduces tumour burden across cancers, with SOAT inhibitors like avasimibe showing promise.

Comprehensive Analysis of Spatial Architecture in Primary Liver Cancer

This study constructs high-resolution spatial transcriptomes of primary liver cancers to analyze spatial architecture and identify tumor microenvironment features.

Live-Cell Imaging of (p)ppGpp with RNA-based Fluorescent Sensors

This paper develops RNA-based fluorescent sensors to directly image and measure (p)ppGpp in live bacterial cells, revealing cell-to-cell variation and dynamics under different nutritional conditions.

Ultrapotent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants

This study identifies three ultrapotent SARS-CoV-2 neutralizing antibodies effective against B.1.351 variants, showing synergistic effects and protective efficacy in mice.